Air separation products (oxygen, nitrogen, argon and others) basically results with use of processes and equipment of cryogenic technical equipment. Manufacture and application of cryoproducts at the initial stage has found out their high potential danger caused by demonstration of specific factors. Therefore simultaneously with development of technical equipment for low-temperature air separation and expansion the spheres of application of received products were improved scientific bases and technological receptions of safety. It has allowed for experts to save up experience and an extensive knowledge at present, to develop effective technological and design decisions for creation of the equipment with a high degree of explosion safety. The basic stages of decision of a problem are considered in historical sequence, methods and means of maintenance of explosion safety for modern air separation plants are stated.